HCID 13841662, compound → HCID 20227710, compound

HRID 1731521Notes

Reaction equation

HRID 1731521 reaction equation
Cl.[Cl:2][CH2:3][CH:4]([CH2:21]Cl)[CH:5]1[C:14]2[C:9](=[CH:10][C:11]([O:18][CH2:19][CH3:20])=[C:12]([O:15][CH2:16][CH3:17])[CH:13]=2)[CH2:8][CH2:7][NH:6]1>C(O)C.CCOCC>[ClH:2].[Cl:2][CH2:3][CH:4]1[CH:5]2[C:14]3[C:9]([CH2:8][CH2:7][N:6]2[CH2:21]1)=[CH:10][C:11]([O:18][CH2:19][CH3:20])=[C:12]([O:15][CH2:16][CH3:17])[CH:13]=3

Participants

3

Reactant 1

HCID 13841662HCID 13841662, compound

Product 1

HCID 20227710HCID 20227710, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

Following the procedure described in Example 2 but using 1-[bis(chloromethyl)-methyl]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride as a starting material, the aimed compound is obtained with a melting point of 130° to 131° C. (ethanol/ether).

Sources & evidence

ORD record
ord-de98b15e4f7e400dbba34fb86bfd3b7a
Source dataset
uspto-grants-1986_11
Patent number
US04622327

Reaction notes

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