HCID 54220868, compound → HCID 13829867, compound

Participants

Reaction Steps

28.7 g (0.11 mole) of methyl 6-(3-hydroxymethylbicyclo[2.2.1]hept-2-yl)-hex-2-enoate are hydrogenated in 450 ml of methanol, with the addition of 12 g of palladium-on-charcoal (5% strength), at 60° C. under a pressure of 30 bar for 11/2 hours. The catalyst is removed by filtration, the methanol is evaporated off in vacuo and the oil which remains is chromatographed on silica gel, using methylene chloride/methanol (99:1), to give 25.5 g (91% yield) of methyl 6-(3-hydroxymethyl-bicyclo[2.2.1]hept-2-yl)-hexanoate.

Provenance & Evidence