HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 20227988, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2-Amino-1-(3-chlorophenyl)ethan-1-ol | HCID 3751601 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-(3-fluoro-4-methoxyphenyl)propan-2-one | HCID 20228002 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 20227988 | HCID 20227988 | — |
Reaction Steps
1-(3-Fluoro-4-methoxyphenyl)propan-2-one (2.73 g) and 2-hydroxy-2-(3-chlorophenyl)ethanamine (2.58 g) were condensed and subsequently reduced with sodium borohydride (2.0 g) by a procedure analogous to that described in Example 1, except dichloromethane was used instead of ethyl acetate in the work-up. Chromatography of the residue on silica gel in 5% methanol-dichloromethane gave N-[2-(3-fluoro-4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine, mp 93°-5° C. (diethyl ether) as a 55:45 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04622342 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-104b1bbeca2042ceacc1f870e05fa814 |
| Source note | uspto-grants-1986_11 |