HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(p-Methoxyphenyl)-2-propanone → HCID 18628127, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(p-Methoxyphenyl)-2-propanone | HCID 31231 | — |
| Reactant | 2-Amino-1-(3-chlorophenyl)ethan-1-ol | HCID 3751601 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Product | HCID 18628127 | HCID 18628127 | — |
Reaction Steps
1-(4-Methoxyphenyl)propan-2-one (2.9 g) and 2-hydroxy-2-(3-chlorophenyl)ethanamine (3.03 g) were condensed and subsequently reduced with sodium borohydride (3.55 g) by an analogous procedure to that described in Example 1. The crude product was recrystallised from diethyl ether-hexane to give N-[2-(4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine, mp 80°-7° C., as a 45:55 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04622342 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-3ef183f0f6c440d2ae3d0c34814dac0e |
| Source note | uspto-grants-1986_11 |