HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(p-Methoxyphenyl)-2-propanone → N-[2-(4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-bromophenyl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(p-Methoxyphenyl)-2-propanone | HCID 31231 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2-Amino-1-(3-bromophenyl)ethan-1-ol | HCID 22021067 | — |
| Product | N-[2-(4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-bromophenyl)ethanamine | HCID 20227986 | — |
Reaction Steps
1-(4-Methoxyphenyl)propan-2-one (3.10 g) and 2-hydroxy-2-(3-bromophenyl)ethanamine (4.08 g) were condensed and subsequently reduced with sodium borohydride (3.8 g) by an analogous procedure to that described in Example 1. The crude product was recrystallised from diethyl ether-hexane to give N-[2-(4-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-bromophenyl)ethanamine, mp 79°-83° C., as a 47:53 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04622342 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-994e83e9ad374ade8f510e3175305381 |
| Source note | uspto-grants-1986_11 |