HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-isopropoxyphenyl)propan-2-one → HCID 20227985, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-isopropoxyphenyl)propan-2-one | HCID 919332 | — |
| Reactant | 2-Amino-1-(3-chlorophenyl)ethan-1-ol | HCID 3751601 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 20227985 | HCID 20227985 | — |
Reaction Steps
1-(4-Isopropoxyphenyl)propan-2-one (1.92 g) and 2-hydroxy-2-(3-chlorophenyl)ethanamine (1.71 g) were condensed and subsequently reduced with sodium borohydride (2.00 g) by an analogous procedure to that described in Example 1. Chromatography of the crude product on silica gel using 1% methanol-dichloromethane as eluent gave N-[2-(4-isopropoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine, mp 58°-61° C. (hexane) as a 42:58 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04622342 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-37a958ad7a114563b13d902f875dd658 |
| Source note | uspto-grants-1986_11 |