2-Methoxyphenylacetone → HCID 18627981, compound

HRID 1731579Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10](=O)[CH3:11].[OH:13][CH:14]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[CH:18]=1)[CH2:15][NH2:16]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH:10]([NH:16][CH2:15][CH:14]([OH:13])[C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[CH:18]=1)[CH3:11]

Participants

Reactant 2

HCID 788872-Methoxyphenylacetone

HCID 37516012-Amino-1-(3-chlorophenyl)ethan-1-ol

Product 1

HCID 18627981HCID 18627981, compound

Procedure

N-[2-(2-methoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine, m.p. 85°-7° C. was prepared from 1-(2-methoxyphenyl)propan-2-one (2.69 g) and 2-hydroxy-2-(3-chlorophenyl)ethanamine (2.81 g) as a 32:68 mixture of diastereoisomers, by an analogous procedure to that described in Example 1.

Sources & evidence

ORD record: ord-f76833b25ad0426cac0e31e9df7c47e8
Source dataset: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04622342

Reaction notes

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