Phosgene → HCID 20228142, compound

HRID 1731595Notes

Reaction equation

HRID 1731595 reaction equation
[C:1]([Cl:4])([Cl:3])=O.[CH:5]([C:8]1[C:9](=[O:16])[N:10](C)[C:11](S)=[N:12][N:13]=1)([CH3:7])[CH3:6]>C(O)(=O)C>[ClH:3].[Cl:4][C:1]1[N:10]([CH3:11])[C:9](=[O:16])[C:8]([CH:5]([CH3:7])[CH3:6])=[N:13][N:12]=1

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 178440400HCID 178440400, compound

Product 1

HCID 20228142HCID 20228142, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 34.6 g (0.35 mole) of phosgene in 600 ml of acetic acid are added 60 g (0.35 mole) of 6-isopropyl-4-methyl-3-mercapto-1,2,4-triazin-5(4H)-one. After the slightly exothermic reaction has subsided, the reaction mixture is stirred for 1 hour at 25° C. The precipitate is isolated by filtration and washed with a small amount of ethyl acetate, affording 64.5 g (90% of theory) of 3-chloro-6-isopropyl-4-methyl-1,2,4-triazin-5(4H)-one hydrochloride with a melting point of 120° C. (dec.).

Workup

  1. customAfter the slightly exothermic reaction
  2. customThe precipitate is isolated by filtration
  3. washwashed with a small amount of ethyl acetate

Sources & evidence

ORD record
ord-0ac93d43729444cd8e98aa6600ced602
Source dataset
uspto-grants-1986_11
Patent number
US04622397

Reaction notes

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