Dimethylamine → HCID 20228138, compound

Participants

Reaction Steps

30.0 g (0.15 mole) of 3-chloro-6-isopropyl-4-methyl-1,2,4-triazin-5(4H)-one hydrochloride are suspended in 60 ml of toluene. With gentle cooling, a solution of 20.4 g (0.45 mole) of dimethylamine in 80 ml of toluene is run into the above still just stirrable mixture at about 30° C. over 2 minutes. The cooling is removed and the reaction mixture exotherms to 50° C. The reaction is complete after stirring for 15 minutes. The mixture is thoroughly stirred in 50 ml of cold water and the organic phase is separated, dried over magnesium sulfate and evaporated to dryness, affording a pale beige-coloured, clear oil in quantitative yield. Distillation yields 21.4 g (72.8%) of 3-dimethylamino-6-isopropyl-4-methyl-1,2,4-triazin-5(4H)-one as a clear, colourless oil with b.p. 135° C./0.04 mm.

Provenance & Evidence