Formaldehyde → HCID 13732648, compound

Participants

Reaction Steps

1.50 g. of the resultant compound of Example 6, 0.15 g. 5% Pd/C in 95 ml. methanol, 5 ml. 37% formaldehyde and 0.8 g. sodium acetate were hydrogenated at 3 atmospheres. The solution was concentrated after removal of the catalyst and the residue was made basic with KOH in water. This was extracted with CHCl3, dried (K2CO3) and concentrated. The residue was dissolved in acetonitrile and acidified with hydrochloric acid in ether to get 1.40 g. product, m.p. 160°-162° C.

Provenance & Evidence