Ethyl bromoacetate → HCID 13116829, compound

Participants

Reaction Steps

A mixture of 41.0 g (0.104 mol) of the R enantiomer of 2-[3-(2,6-dichloro-4-trifluoromethyl-phenoxy)phenoxy]-propionic acid, 15.8 g (0.114 mol) of potassium carbonate and 17.4 g (0.104 mol) of ethyl bromoacetate in 104 ml of acetonitrile was heated under reflux for 1 hour. Thereafter, working-up was carried out by filtering the reaction mixture under suction, evaporating down the filtrate, taking up the remaining residue in methylene chloride, and washing this solution once with water, drying it and then evaporating it down. The remaining residue was freed from residues of volatile constituents by gentle heating in a high vacuum. In this manner, 34.9 g (70% of theory) of the R enantiomer of (ethoxycarbonyl)-methyl 2-[3-(2,6-dichloro-4-trifluoromethylphenoxy)-phenoxy]-propionate were obtained in the form of a liquid having a refractive index nD20 =1.5190.

Provenance & Evidence