Thionyl Chloride → HCID 13391440, compound

HRID 1731623Notes

Reaction equation

S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([Cl:29])[C:7]=1[O:8][C:9]1[CH:10]=[C:11]([CH:18]=[CH:19][CH:20]=1)[O:12][CH:13]([CH3:17])[C:14](O)=[O:15]>C1(C)C=CC=CC=1>[Cl:29][C:21]1[CH:22]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:24]=[C:6]([Cl:5])[C:7]=1[O:8][C:9]1[CH:10]=[C:11]([CH:18]=[CH:19][CH:20]=1)[O:12][CH:13]([CH3:17])[C:14]([Cl:3])=[O:15]

Participants

Conditions

Temperature: 100 °C

Procedure

15 g (0.126 mol) of thionyl chloride were added dropwise to a stirred solution of 19.7 g (0.05 mol) of the R enantiomer of 2-[3-(2,6-dichloro-4-trifluoromethylphenoxy)-phenoxy]-propionic acid in 100 ml of toluene at 20° C. The mixture was heated to 100° C. for 2 hours. Thereafter, the reaction mixture was evaporated down by stripping off the volatile constituents under reduced pressure. In this manner, the R enantiomer of 2-[3-(2,6-dichloro-4-trifluoromethyl-phenoxy)-phenoxy]-propionic acid-chloride was obtained in the form of an oily product, which was used for the further reaction. ##STR37##

Workup

customThereafter, the reaction mixture was evaporated down

Sources & evidence

ORD record: ord-2c5154ba1e06467682b3ab346571c230
Source dataset: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04622415

Reaction notes

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