Dimethyl Sulfoxide → HCID 13746709, compound

Participants

Reaction Steps

A mixture of ethyl 3-(7-cyano-10,11-dihydrodibenzo[b,f]thiepin-2-yl)-2-ethoxycarbonylpropanoate (4.025 g; 4.84 mmole), water (354 mg; 19.7 mmole), sodium chloride (576 mg) and dimethylsulfoxide (100 ml) are heated together under argon in an oil bath at 200°-205° C. for 3 hours. The cool reaction mixture was diluted with methylene chloride and the solution was extracted with water (3×100 ml), then dried (MgSO4) and evaporated to an oil (3.223 g; 97%). The pure title compound was obtained by short path distillation of the crude product (oven temperature 200° C./0.05 Torr).

Provenance & Evidence