HCID 13746705, compound → HCID 13746710, compound

HRID 1731634Notes

Reaction equation

[C:1]([C:3]1[CH:29]=[CH:28][C:6]2[CH2:7][CH2:8][C:9]3[CH:15]=[C:14](CC(C(OCC)=O)C(OCC)=O)[CH:13]=[CH:12][C:10]=3[S:11][C:5]=2[CH:4]=1)#[N:2].C(C1C=CC2CCC3C=CC=[C:41]([C:45]([C:50]([O:52][CH2:53][CH3:54])=[O:51])(C)C([O-])=O)C=3SC=2C=1)#N>>[C:1]([C:3]1[CH:29]=[CH:28][C:6]2[CH2:7][CH2:8][C:9]3[CH:15]=[CH:14][CH:13]=[C:12]([CH2:41][CH2:45][C:50]([O:52][CH2:53][CH3:54])=[O:51])[C:10]=3[S:11][C:5]=2[CH:4]=1)#[N:2]

Participants

Reactant 2

HCID 13746705HCID 13746705, compound

HCID 86741105HCID 86741105, compound

Product 1

HCID 13746710HCID 13746710, compoundYield 97%

Procedure

Substituting ethyl 3-(7-cyano-10,11-dihydrodibenzo[b,f]thiepin-2-yl)-2-ethoxycarbonylpropanoate in the foregoing example with an equivalent amount of ethyl 3-(7-cyano-10,11-dihydrodibenzo[b,f]-thiepin-4-yl-2-ethoxycarbonylpropanoate provided the title compound in 97% yield. The compound was purified by short-path distillation at an oven temperature of 190°/0.05 Torr and then has m.p. 61°-62° C. Analysis for: C20H19NO2S Requires: C 71.19, H 5.68, N 4.15, S 9.50; Found C 71.13, H 5.80, N 4.09, S 9.42.

Sources & evidence

ORD record: ord-2cdca1ef31364e3da1700ee6f2539023
Source dataset: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04622403

Reaction notes

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