Hydrochloric Acid → HCID 20228203, compound

Participants

Reaction Steps

1-Oxo-2,3,11,12-tetrahydro-1H-benzo[b]indeno[4,5-f]thiepin-8-carboxylic acid (50 mg; 0.16 mmole) was added in portions over a 3/4 hour period to a refluxing mixture of acetic acid (4 ml), concentrated hydrochloric acid (0.3 ml) and amalgamated "mossy" zinc (220 mg) under argon. After a further 3 hours under reflux no oxo-acid remained. The reaction mixture was filtered, evaporated to a small volume and diluted with a little water to afford 43 mg of the title compound.

Provenance & Evidence