HCID 13746717, compound → HCID 20228228, compound

HRID 1731642Notes

Reaction equation

HRID 1731642 reaction equation
O=[C:2]1[C:15]2[C:14]3[S:13][C:12]4=[CH:16][CH2:17][CH2:18][CH:19]=[C:11]4[CH:10]=[C:9]([C:20]([OH:22])=[O:21])[C:8]=3[CH:7]=[CH:6][C:5]=2[CH2:4][CH2:3]1.O=C1C2C3CCC4C=CC(C(O)=O)=CC=4SC=3C=CC=2CC1>>[CH2:2]1[C:15]2[C:14]3[S:13][C:12]4=[CH:16][CH2:17][CH2:18][CH:19]=[C:11]4[CH:10]=[C:9]([C:20]([OH:22])=[O:21])[C:8]=3[CH:7]=[CH:6][C:5]=2[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 13746717HCID 13746717, compoundHCID 20228202HCID 20228202, compound

Product 1

HCID 20228228HCID 20228228, compound

Procedure

Substituting an equivalent amount of 1-oxo2,3,9,10-tetrahydro-1H-benzo[b]indeno[5,4-f]thiepin-6-carboxylic acid in Example 41 in place of 1-oxo2,3,11,12-tetrahydro-1H-benzo[b]indeno[4,5-f]thiepin-8-carboxylic acid and heating under reflux for 9 hours instead of 3 hours yielded the title compound.

Workup

  1. temperatureheating
  2. temperatureunder reflux for 9 hours instead of 3 hours

Sources & evidence

ORD record
ord-645e3c7bf23e44ca89ff93185df59085
Source dataset
uspto-grants-1986_11
Patent number
US04622403

Reaction notes

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