HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → Methanesulfonic acid 2-tert-butoxycarbonylamino-2-methyl-propyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | tert-butyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate | HCID 14578673 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Methanesulfonic acid 2-tert-butoxycarbonylamino-2-methyl-propyl ester | HCID 11659022 | — |
Reaction Steps
N-Boc-2-Amino-2-methylpropanol is dissolved in triethylamine under argon at 0° C. Methanesulfonyl chloride is added and the mixture is stirred overnight. The solution is poured into 10% aqueous citric acid and extracted with ethyl acetate. The organic layer is dried over MgSO4, filtered and evaporated to give N-Boc-2-amino-2-methyl-1-propyl mesylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04622418 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-1daaed1333b0417c894a458442020ffa |
| Source note | uspto-grants-1986_11 |