HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → N-Boc-1-amino-1-hydroxymethylcyclopropane mesylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | tert-butyl N-(1-(hydroxymethyl)cyclopropyl)carbamate | HCID 11286907 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-Boc-1-amino-1-hydroxymethylcyclopropane mesylate | HCID 20165745 | — |
Reaction Steps
N-Boc-1-amino-1-hydroxymethylcyclopropane is dissolved in triethylamine under argon at 0° C. Methanesulfonyl chloride is added with a syringe and the contents stirred at room temperature overnight. The solution is poured into 10% aqueous citric acid and extracted with ethyl acetate. The organic layer is dried over MgSO4 filtered and evaporated to give N-Boc-1-amino-1-hydroxymethylcyclopropane mesylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04622418 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-60c5c6e580734116b9ce408e86e4d0a5 |
| Source note | uspto-grants-1986_11 |