Hydrochloric Acid → HCID 67894920, compound

Participants

Reaction Steps

To a solution of benzhydryl 7-(2-hydroxybenzylideneamino)-3-[(Z)-2-(3-pyridyl)vinylthiomethyl]-3-cephem-4-carboxylate (2.3 g) in ethyl acetate (46 ml) was added concentrated hydrochloric acid (1 ml) at ambient temperature and the mixture was stirred for 30 minutes to give a precipitate of a viscous oil. The upper layer was removed by decantation and the resultant oil was triturated with a mixture of ethanol and diethyl ether to give benzhydryl 7-amino-3-[(Z)-2-(3-pyridyl)vinylthiomethyl]-3-cephem-4-carboxylate dihydrochloride (2.2 g).

Provenance & Evidence