m-Chloroperbenzoic acid → HCID 54410203, compound

Participants

Reaction Steps

A solution of meta-chloroperbenzoic acid (85% pure) (0.05 g) in methylene chloride (1 cc) is added all at once to a solution, cooled to -10° C., of product (8b) (0.2 g) in methylene chloride (5 cc). After 30 minutes at -10° C., the reaction mixture is diluted with ethyl acetate (20 cc) and washed with a saturated solution of sodium bicarbonate (2×10 cc) and a saturated solution of sodium chloride (2×10 cc). After the mixture has been dried over sodium sulphate and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 30° C., crude syn isomer of 2-benzhydryloxycarbonyl-3-(2,2-dichloroethyl)-7-[2-methoxyimino-2-(2-tritylaminothiazol-4-yl)-acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-5-oxide (product 8) (0.15 g) is obtained in the form of a hard orange foam.

Provenance & Evidence