反应详情

Sodium methoxide (243 g) is cautiously added to a solution of 3-chloro-4-methyl-6-phenylpyridazine (307 g, 1.5 mol) in 3.4 L of methanol. The mixture is heated to refluxing temperature for approximately eight hours under an atmosphere of nitrogen and then poured into water (4.5 L). The resulting precipitate is collected, washed with water, and dried to give 270 g (90%) of product with a melting point of 62°-64° C.

1. temperatureThe mixture is heated
2. temperatureto refluxing temperature for approximately eight hours under an atmosphere of nitrogen
3. customThe resulting precipitate is collected
4. washwashed with water
5. customdried