Dimethylamine → HCID 20226927, compound

Participants

Reaction Steps

A 1.5 g sample of 3-chloro-4,5-dimethyl-6-phenylpyridazine is placed in a 6 oz. glass pressure bottle and covered with 15 mL of condensed dimethylamine. To this mixture is added several drops of HI. The bottle is then closed, fitted with a pressure guage and heated for 50 hours at 90°-100° C. and 85-100 psig pressure. The mixture is cooled, excess dimethylamine is evaporated, and the residue partitioned between CH2Cl2 and water. The organic layer is separated and dried over MgSO4. Removal of the drying agent and concentration of the solvent in vacuo leaves a brown solid (1.7 g). The crude solid is boiled in cyclohexane, filtered; the filtrate diluted with hexane and chilled. The product (0.7 g) is isolated as a mustard-colored solid which melts at 86°-89° C.

Provenance & Evidence