HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 14595362, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-(6,7-Diethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)propane-1,3-diol | HCID 13696685 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 14595362 | HCID 14595362 | 70% |
Reaction Steps
10 mmoles (2.8 g) of 1-[bis(hydroxymethyl)-methyl]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline and 11 mmoles (1.17 g) of freshly distilled benzaldehyde are refluxed in 50 ml of absolute benzene, in the presence of a catalytic amount of hydrochloric acid or acetic acid for 4 hours. The solvent is distilled off and the residual pale-yellow oil is crystallized by trituration with ether. The aimed compound is obtained in a yield of 70%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04623647 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-5079358a12114027ba98dfdbee244771 |
| Source note | uspto-grants-1986_11 |