Thionyl Chloride → HCID 20227175, compound

Participants

Reaction Steps

0.01 mole (3.08 g) of 1-(hydroxymethyl)-9,10-diethoxy-1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino[4,3-a]-isoquinoline is dissolved in 50 ml of absolute benzene. To the solution 0.05 mole (6 g) of sulfinyl dichloride is added dropwise, under ice cooling and stirring. Thereafter the reaction mixture is slightly refluxed for 3 hours. The excess of the solvent and sulfinyl dichloride is distilled off in vacuo. The residual brown oil is triturated with a small amount of ether to yield the desired compound in crystalline form in a yield of 37%.

Provenance & Evidence