HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → N,N'-diisopropyl-O-(m-methoxycarbonylbenzyl)-isourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | Benzoic acid, 3-(hydroxymethyl)-, methyl ester | HCID 155058 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | N,N'-diisopropyl-O-(m-methoxycarbonylbenzyl)-isourea | HCID 14760215 | 96% |
Reaction Steps
A mixture of 4.75 g (28.6 mmols) of m-methoxycarbonylbenzyl alcohol and 3.6 g (28.6 mmols) of N,N'-diisopropylcarbodiimide was stirred with 50 mg (0.51 mmols) of cuprous chloride at room temperature for 24 hours. The reaction was then diluted with 10 ml of hexane and eluted through a short column of neutral alumina with 20% ethyl acetate-hexane to give 8.0 g (96%) of N,N'-diisopropyl-O-(m-methoxycarbonylbenzyl)-isourea as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04623645 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-92fcff4cab4e4f6b9d3de233be285761 |
| Source note | uspto-grants-1986_11 |