Sulfur → HCID 13505212, compound

Participants

Reaction Steps

435 mg (1.3 mmol) of 6-(1-cyclohexen-4-yl)-4-methyl-β-carboline-3-carboxylic acid ethyl ester is heated in 10 ml of dimethyl sulfoxide with 125 mg of sulfur under nitrogen for 2 hours to 180° C. After evaporation under vacuum, the reaction mixture is distributed in methylene chloride/saturated sodium bicarbonate solution. The methylene chloride phase is evaporated and the residue chromatographed over silica gel with toluene:glacial acetic acid:water=10:10:1 as the eluent. After evaporation of the corresponding fractions and mixing with hexane under agitation, 48 mg (8.4% of theory) of 6-phenyl-4-methyl-β-carboline-3-carboxylic acid ethyl ester is obtained, mp 241°-242° C.

Provenance & Evidence