Acetic Acid → HCID 53672638, compound

Participants

Reaction Steps

260 mg of 6-benzoyl-4-methyl-β-carboline-3-carboxylic acid ethyl ester is hydrogenated in 36 ml of absolute ethanol with 2 ml of glacial acetic acid and 100 mg of palladium black for 2 hours at 10 bar hydrogen pressure at 40°-45° C. After separation of the catalyst, the reaction mixture is evaporated. The residue is chromatographed over silica gel, first with toluene:glacial acetic acid:water=10:10:1 and then with toluene:ethanol:water=80:20:1, thus obtaining 27 mg (11%) of 6-benzyl-4-methyl-β-carboline-3-carboxylic acid ethyl ester.

Provenance & Evidence