HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(2,4,6-Trimethylphenyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 2',4',6'-trimethyl[1,1'-biphenyl]-4-carboxylate | HCID 13143477 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(2,4,6-Trimethylphenyl)benzoic acid | HCID 22730467 | — |
Reaction Steps
The compound from Example 9 part (a) (1.3 g) was dissolved in a mixture of isopropanol (15 mL) and water (8 mL). Lithium hydroxide (1.3 g) was added and the reaction mixture was refluxed. After 2 hours the solution was poured into 2N HCl and the product was extracted into ether. After drying the organic phase with MgSO4 and evaporation a white solid was obtained (1.15 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04623661 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-d2145a7a1e014b239e4c56642e7dd905 |
| Source note | uspto-grants-1986_11 |