p-Toluenesulfonic acid → HCID 70452876, compound

Participants

Reaction Steps

2,3-Dihydropyran (4.6 g.) and a few crystals of toluene-p-sulphonic acid were added to a solution of 4-hydroxy-α-methyldesoxybenzoin (11.3 g.) in chloroform (100 ml.). The resulting solution was heated under reflux for 5 mins., cooled and washed with 5% w/v aqueous sodium bicarbonate solution. The chloroform solution was then dried and evaporated, and the residue crystallised from acetone to give 4-(2-tetrahydropyranyloxy)-α-methyldesoxybenzoin (5.93 g.), m.p. 94°-96° C.

Provenance & Evidence