Nitric Acid → 2-Bromo-1,3-difluoro-4-nitrobenzene

Participants

Reaction Steps

A mixture of 10 ml concentrated HNO3 and 10 ml concentrated H2SO4 was added dropwise with cooling to a stirred solution of 30 g 2,6-difluorobromobenzene in 50 ml of concentrated sulfuric acid. The rate of addition was controlled such that the temperature of the mixture did not rise above 55° C. After the addition was complete the reaction mixture was allowed to stir at room temperature for 2 hours. It was then poured onto ice and the resulting solid was collected by filtration, washed with water and dried, yielding a pale yellow solid, m.p. 50°-51.5° C., 84% yield (31.2 g).

Provenance & Evidence