HCID 13732855, compound → HCID 20227232, compound

Participants

Reaction Steps

A solution of 5.92 g 3-(3-t-butyldimethylsilyloxymethylphenyl)-4-fluoronitrobenzene in 200 ml 50% ethyl acetate/hexanes was hydrogenated over 5 g of 5% palladium on carbon at 50 p.s.i. for 15 minutes. The reaction mixture was filtered and evaporated to yield the crude product (5.43 g, 100% yield) which was used directly without further purification. On purification, the compound is characterized by the following data: NMR (CDCl3, 250 MHz): 7.45 (m, 4H), 6.98 (dd, 1H), 6.75 (dd, 1H), 6.62 (8 line multiplet, 1H), 4.8 (s, 2H), 3.6 (br s, 2H), 0.95 (s, 9H), 0.01 (s, 6H).

Provenance & Evidence