1-Bromo-2-fluorobenzene → 2-Fluoro-4'-methyl-1,1'-biphenyl

Participants

Reaction Steps

6.0 g (57% yield) was prepared as an oil by the method of Example 19A from 10 g 2-bromofluorobenzene, 250 mg bis(diphenylphosphinylethane)nickel dichloride and 89 ml 0.73M 4-toluylmagnesium bromide. The product was used without further purification. NMR (CDCl3, 60 MHz): 7.5-6.9 (m, 8H), 2.3 (s, 3H).

Provenance & Evidence