Imidazole → HCID 54236465, compound

HRID 1731809Notes

Reaction equation

HRID 1731809 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]1[CH:18]=[CH:17][C:14]([CH2:15][OH:16])=[CH:13][CH:12]=1.N1C=CN=C1.[Si:24](Cl)([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25]>>[Si:24]([O:16][CH2:15][C:14]1[CH:17]=[CH:18][C:11]([C:3]2[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=2[F:1])=[CH:12][CH:13]=1)([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25]

Participants

4

Reactant 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 13732857HCID 13732857, compound

Product 1

HCID 54236465HCID 54236465, compoundYield 98%

Procedure

6.0 g (98% yield was prepared by the method of Example 19E from 4.2 g 4-(2-fluoro-5-nitrophenyl)benzyl alcohol, 2.5 g imidazole and 3.5 g t-butyldimethylsilyl chloride. The oil was used without further purification.

Workup

  1. customThe oil was used without further purification

Sources & evidence

ORD record
ord-079e17dbacf34c97b919ce142832fada
Source dataset
uspto-grants-1986_11
Patent number
US04623650

Reaction notes

Loading…