Hydrochloric Acid → HCID 13732846, compound

Participants

Reaction Steps

A mixture of ethyl 10-bromo-9-fluoro-3-methyl-7-oxo-2,3-dihydro-(7H)-pyrido-(1,2,3-de)-1,4-benzoxazine-6-carboxylate (0.2 g, 0.54 mmol) and a 3N hydrochloric acid solution (15 ml) were heated at 100° C. with stirring for 17 hours. The reaction mixture was diluted twofold with water and filtered. The white solid, which was collected, was washed with water, triturated with acetone, and filtered. Drying in vacuo afforded a white powder (142 mg, 77% yield): m.p. >250° C. NMR (5% DMSO-d6/CF3CO2D, 250 MHz): 9.12 (s, 1H), 7.80 (d, 1H, J=8 Hz), 5.10-5.00 (m, 1 H), 4.80-4.70 (m, 1H), 4.60-4.50 (m, 1H), 1.52 (d,3H, J=7 Hz).

Provenance & Evidence