2,4-Difluorophenyl isocyanate → N-[(4-Butylphenyl)methyl]-N'-(2,4-difluorophenyl)-N-heptylurea

HRID 1731853Notes

Reaction equation

HRID 1731853 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]=[C:10]=[O:11].[CH2:12]([NH:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][CH2:29][CH3:30])=[CH:23][CH:22]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>CCCCCC>[CH2:27]([C:24]1[CH:23]=[CH:22][C:21]([CH2:20][N:19]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([NH:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[O:11])=[CH:26][CH:25]=1)[CH2:28][CH2:29][CH3:30]

Participants

4

Reactant 2

HCID 5932582,4-Difluorophenyl isocyanateHCID 15137718N-heptyl-4-butylbenzenemethanamine

Product 1

HCID 13733119N-[(4-Butylphenyl)methyl]-N'-(2,4-difluorophenyl)-N-heptylurea

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent2×

Procedure

A solution of 1.55 g of 2,4-diflurophenylisocyanate in hexane was added to a solution of 2.61 g of N-heptyl-4-butylbenzenemethanamine in 15 ml of hexane and the solution was stirred at room temperature for 4 hours, then evaporated. The residual oil was distilled to yield 1-[(4-butylphenyl)methyl]-1-(n-heptyl)-3-[2,4-difluorophenyl]urea as a colorless oil, bp 160°-165° C./120μ.

Workup

  1. customevaporated
  2. distillationThe residual oil was distilled

Sources & evidence

ORD record
ord-16b2f0f657c84822974148bf3b7ece86
Source dataset
uspto-grants-1986_11
Patent number
US04623662

Reaction notes

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