HCID 13733127, compound → HCID 13733072, compound

HRID 1731856Notes

Reaction equation

HRID 1731856 reaction equation
C1(O[C:8](=[O:19])[NH:9][C:10]2[C:15]([CH3:16])=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=2[CH3:18])C=CC=CC=1.[CH3:20][C:21]([CH3:37])([CH3:36])[CH2:22][CH2:23][NH:24][CH2:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][CH2:34][CH3:35])=[CH:28][CH:27]=1>C1(C)C=CC=CC=1>[CH2:32]([C:29]1[CH:28]=[CH:27][C:26]([CH2:25][N:24]([CH2:23][CH2:22][C:21]([CH3:20])([CH3:37])[CH3:36])[C:8]([NH:9][C:10]2[C:11]([CH3:18])=[CH:12][C:13]([Cl:17])=[CH:14][C:15]=2[CH3:16])=[O:19])=[CH:31][CH:30]=1)[CH2:33][CH2:34][CH3:35]

Participants

4

Reactant 2

HCID 13733127HCID 13733127, compoundHCID 13733131HCID 13733131, compound

Product 1

HCID 13733072HCID 13733072, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 825 mg of phenyl-N-(4-chloro-2,6-dimethylphenyl]carbamate and 740 mg of N-[3,3-dimethylbutyl]-4-n-butylbenzenemethanamine in 40 ml of toluene was refluxed for 1 hour, cooled, and the solution was washed with 1N sodium hydroxide, brine, dried, and evaporated to dryness to yield a solid. The solid was recrystallized from hexane to yield 1-[(4-butylphenyl)methyl]-1-[3,3-dimethylbutyl]-3-[4-chloro-2,6-dimethylphenyl]urea as a white solid, mp 138°-139° C.

Workup

  1. temperaturecooled
  2. washthe solution was washed with 1N sodium hydroxide, brine
  3. customdried
  4. customevaporated to dryness
  5. customto yield a solid
  6. customThe solid was recrystallized from hexane

Sources & evidence

ORD record
ord-81ee777727be48d484da007b047986aa
Source dataset
uspto-grants-1986_11
Patent number
US04623662

Reaction notes

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