Acetic Acid → L-Fructose

Participants

Reaction Conditions

Reaction Steps

Compound 3 (3 g) dissolved in 60% acetic acid (30 ml) was heated at 40° C. for 3 hours. The mixture was made alkaline with 10N sodium hydroxide solution (40 ml), heated at 70° C. for 15 hours and then acidified with 18N sulfuric acid solution (30 ml). The salt was filtered off and the filtrate left at room temperature for 18 hours and 70° C. for 2 hours. The mixture was neutralized with 10N sodium hydroxide solution (3.5 ml). The salt was removed by ethanol precipitation. After filtration, the filtrate was concentrated, deionized with a column of Amberlite MG-1 ion-exchange resin, and eluted with water. The effluent was concentrated to give L-fructose as a syrup (1.21 g, 76%).

Provenance & Evidence