Acetic Acid → L-Fructose

Participants

Reaction Conditions

Reaction Steps

Compound 10 was stirred in 30% acetic acid at 55° C. for 5 hours. The solution was brought to pH of about 10 with 10N sodium hydroxide and heated at 40° C. for 3 hours. The reaction mixture was acidified with 10N sulfuric acid and heated at 80° C. with stirring for 30 minutes. The reaction mixture was neutralized with 10N sodium hydroxide and the salt was removed by repeated precipitation with ethanol. After filtration, the filtrate was concentrated to give L-fructose as a syrup in more than 85% yield.

Provenance & Evidence