HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 13604908, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | HCID 20227416 | HCID 20227416 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 13604908 | HCID 13604908 | 32% |
Reaction Steps
The 1-(3-phenylpropyl)-3-(4-fluoro-3-methoxyphenyl)piperidine from Preparation 5 was reacted with 48% aqueous hydrobromic acid in glacial acetic acid using the procedure of Example 3. The product was chromatographed on silica gel, eluting with ethyl acetate/hexane/triethylamine (5:5:3). This afforded a 32% yield of the title compound, [alpha]D25 =-21.2° (c=1; C2H5OH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04623728 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-05b0f74ce5cb42efac77ffd43d22cfd1 |
| Source note | uspto-grants-1986_11 |