HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenepropanoyl chloride → HCID 20227416, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenepropanoyl chloride | HCID 64801 | — |
| Reactant | HCID 20227422 | HCID 20227422 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20227416 | HCID 20227416 | 96% |
Reaction Steps
The title compound was prepared by acylation of 995 mg (4.75 mmole) of the 3-(4-fluoro-3-methoxyphenyl)piperidine from Preparation 8, Part B, with 1.2 g (7.13 mmole) of 3-phenylpropionyl chloride in toluene, followed by reduction with 831 mg (21.9 mmole) of lithium aluminum hydride in tetrahydrofuran, substantially according to the procedure of Preparation 3. This afforded 1.49 g (96% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04623728 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-898aa8d5bde848f6bd45908ca22ef4f0 |
| Source note | uspto-grants-1986_11 |