Hydrazine hydrate (1:1) → 2-Chloro-3-hydrazino-6-methoxyquinoxaline

Participants

Reaction Steps

2,3-Dichloro-6-methoxyquinoxaline (4.2 g., 0.018 mole), the product of Preparation E(b), and 2.7 ml. of hydrazine hydrate in 100 ml. of ethanol were heated under reflux for 4 hours and stirred at room temperature overnight. The precipitate was removed by filtration and washed with ethanol to afford 3.9 g. (97% yield) of 2-chloro-3-hydrazino-6-methoxy quinoxaline, m.p. <250° C.

Provenance & Evidence