反应详情

2-Chloro-3-hydrazinoquinoxaline (2.2 g., 0.011 mole) was mixed with 6 ml. of triethyl orthobenzoate and heated at 100° C. for 30 minutes. After cooling the orange mixture to room temperature, ethanol was added. Filtration of the resultant precipitate afforded 2.1 g. of crude product which was further purified by means of trituration with warm methanol, followed by filtration and air drying to ultimately yield 1.58 g. (51%) of pure 4-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline as an orange solid.

1. filtrationFiltration of the resultant precipitate
2. customafforded 2.1 g
3. customof crude product which was further purified by means of trituration with warm methanol
4. filtrationfollowed by filtration and air
5. customdrying to ultimately yield 1.58 g