Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trichloroacetic Acid → ASTA-Z-7654(free acid)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trichloroacetic Acid | HCID 6421 | — |
| 반응물 | 4-Hydroxycyclophosphamide | HCID 99735 | — |
| 반응물 | 2-Sulfanylethane-1-sulfonic acid--cyclohexanamine (1/1) | HCID 23049873 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | ASTA-Z-7654(free acid) | HCID 6917796 | — |
반응 단계
1.4 g (5 mmol) of 4-hydroxycyclophosphamide and 1.2 g (5 mmol) of cyclohexylammonium-2-mercaptoethanesulphonate were dissolved together with a trace of trichloroacetic acid in 25 ml of methanol and were left to stand overnight in a refrigerator at -25° C. The reaction solution was then concentrated to about 5 ml, ether was added until clouding commenced and the mixture was triturated. The crystallised material was filtered with suction after standing for 20 hours at 0° C., and was washed and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04623742 |
| 출처 데이터셋 | uspto-grants-1986_11 |
| ORD ID | ord-78d36a09114c45999debc021d0f1fa0b |
| 출처 메모 | uspto-grants-1986_11 |