HuagongsheHuagongshe Chemistry Print Report · For research reference only
Mercaptoethanesulfonic acid → Mafosfamide Sodium Salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Mercaptoethanesulfonic acid | HCID 598 | — |
| Reactant | 4-Hydroxycyclophosphamide | HCID 99735 | — |
| Solvent | Water | HCID 962 | — |
| Product | Mafosfamide Sodium Salt | HCID 104746 | — |
Reaction Steps
0.8 g (3.0 mmol) of 4-hydroxycyclophosphamide in 3 ml of water were mixed with 420 mg (3.0 mmol) of 2-mercaptoethanesulphonic acid, with ice water cooling. After 1 hour, the mixture was concentrated under high vacuum and was crystallised.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04623742 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-619ed1eb67204fd4b7bf039408ffcadd |
| Source note | uspto-grants-1986_11 |