HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → Lodaxaprine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | 3-Chloro-6-(2-chlorophenyl)pyridazine | HCID 12449557 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | Lodaxaprine | HCID 65835 | — |
Reaction Steps
Operation is carried out in accordance with the methods mentioned for preparing 3-chloro-6-(2-chloro-phenyl)pyridazine (m.p.: 146°-147° C.). 5 g of this product are dissolved in 120 ml of normal butanol and mixed with 6.74 g of 4-hydroxy-piperidine, then heated to reflux. By following the modus operandi described for the previous Example, 5 g of CM 40907 are obtained after recrystallization in absolute ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04624952 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-a945df9f5f7e42959e7e4eea044dc266 |
| Source note | uspto-grants-1986_11 |