1-Carbomethoxy-4-benzylpiperazine → Methyl piperazine-1-carboxylate

HRID 1731996Notes

Reaction equation

HRID 1731996 reaction equation
[C:1]([N:5]1[CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7][CH2:6]1)([O:3][CH3:4])=[O:2].[H][H]>C(O)C.[Pd]>[C:1]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)([O:3][CH3:4])=[O:2]

Participants

5

Reactant 2

HCID 32977831-Carbomethoxy-4-benzylpiperazineHCID 178418361HCID 178418361, compound

Product 1

HCID 142729Methyl piperazine-1-carboxylateYield 74%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

34.0 g (0.15 mole) of 1-carbomethoxy-4-benzylpiperazine dissolved in 300 ml of ethanol was treated with hydrogen over a palladium catalyst at 40 psi and room-temperature for 24 hours. The catalyst was removed by filtration and the solvent removed under reduced pressure. The residue was distilled, b.p. 70°-75° C. at 1.5 mmHg to give 16.0 g of 1-carbomethoxypiperazine.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent removed under reduced pressure
  3. distillationThe residue was distilled

Sources & evidence

ORD record
ord-0dd87f470a1f425bad98fd2f56f20fee
Source dataset
uspto-grants-1986_11
Patent number
US04624953

Reaction notes

Loading…