Ethylamine → HCID 13191431, compound

HRID 1732024Notes

Reaction equation

HRID 1732024 reaction equation
[CH2:1]=[C:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:16]([NH2:18])[CH3:17]>C(O)C>[CH2:16]([NH:18][CH2:1][CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH3:17]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 11117162Ethyl alpha-(phenethyl)acrylate

Product 1

HCID 13191431HCID 13191431, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
105 °C

Procedure

17 g of ethyl 2-methylene-4-phenylbutyrate (Example 1.4) and 3.6 g of ethylamine were dissolved in 50 ml of absolute ethanol and heated under 40 atmospheres of nitrogen at 105° C. for 20 hours. After the solvent had been removed, the residue was taken up in 5 normal hydrochloric acid, extracted with ether and the aqueous solution was adjusted to pH 9.5 with potassium carbonate, again extracted with ether, and this was dried with potassium carbonate and evaporated.

Workup

  1. customAfter the solvent had been removed
  2. extractionextracted with ether
  3. extractionagain extracted with ether
  4. dry with materialthis was dried with potassium carbonate
  5. customevaporated

Sources & evidence

ORD record
ord-44807624016d44108191fad246575fc0
Source dataset
uspto-grants-1986_11
Patent number
US04624962

Reaction notes

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