HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1732092Generated: October 30, 2026
Ethylene Glycol → 4-(2-Hydroxyethoxy)-5,5-dimethyltetrahydropyrimidin-2(1H)-one
https://huagongshe.com/reaction/1732092
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | Isobutyraldehyde | HCID 6561 | — |
| Product | 4-(2-Hydroxyethoxy)-5,5-dimethyltetrahydropyrimidin-2(1H)-one | HCID 54048990 | — |
Reaction Steps
60 Parts (1.0 mole) of urea, 30 parts (1.0 mole) of paraformaldehyde, 100 parts (1.6 moles) of ethylene glycol, 72 parts (1.0 mole) of isobutyraldehyde, and 20 parts of 40% sulfuric acid were stirred together and heated at 70° C., thereby forming a thick milky paste. The mixture was then heated for 4 hours at 70° C., forming a slightly hazy solution of 5,5-dimethyl-4-hydroxyethoxytetrahydropyrimidin-2-one, confirmed by IR spectra.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04625029 |
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| Source dataset | uspto-grants-1986_11 |
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| ORD ID | ord-3e3d28f22e434bc893682584544d32c7 |
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| Source note | uspto-grants-1986_11 |
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