HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-6-phenylpyrimidine-2,4(1H,3H)-dione → 1-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-6-phenylpyrimidine-2,4(1H,3H)-dione | HCID 12300350 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | N,N-Dimethylmethanimidamide | HCID 12669390 | — |
| Product | 1-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione | HCID 13086235 | — |
Reaction Steps
A solution of 1-methyl-6-phenyluracil (0.65 g) in dimethylformamidine (15 ml) is treated with 10 percent palladium on carbon and reduced at 40 p.s.i. for 20 hours. The catalyst is then filtered and the filtrate evaporated to a crystalline residue. The crystallization from acetonitrile provides 5,6-dihydro-1-methyl-6-phenyl-2,4-pyrimidine-dione, m.p. 155°-6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04625028 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-4160537650e34c018ad921db6c839db3 |
| Source note | uspto-grants-1986_11 |