Sulfuric Acid → 6-fluoro-2,3-dihydro-4H-1-benzopyran-4-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.00 g of 3-(4-fluorophenoxy)propionitrile and 40 g of 85% sulfuric acid was stirred for 10 hours at 90° C. After cooling, the reaction mixture was poured into a proper amount of ice-water and extracted with ethyl acetate. After an ethyl acetate layer was neutralized with 20% aqueous solution of sodium hydroxide, the layer was dehydrated with anhydrous magnesium sulfate. Ethyl acetate was distilled away to give 861 mg of a white crystal of 6-fluoro-4-chromanone (yield: 43%).

Provenance & Evidence